{"title":"Numbuzin","description":null,"products":[{"product_id":"numbuzin-no5-glutathione-txa-dark-spot-ampoule-pd-0505","title":"Numbuzin — No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate","description":"\u003cp\u003ePigmentation spots and uneven skin tone result from excessive melanin production or distribution, often exacerbated by UV, blemishes, or microtraumas. The most robustly documented anti-spot active ingredients act on several steps of the melanogenic process: TXA blocks melanocyte-keratinocyte communication; glutathione reduces tyrosinase activity and directs melanogenesis towards the lighter pheomelanin pathway; niacinamide inhibits melanosome transfer. This serum combines all three.\u003c\/p\u003e\n\u003cp\u003eNumbuzin's No.5 Glutathione TXA Advanced Dark Spot Ampoule uses a bi-dose PRESS \u0026amp; MIX galenic format. High-purity glutathione, unstable in aqueous solution, is kept in powder form (STEP 2) until activation. By pressing the cap, the powder is released into the concentrated ampoule (STEP 1) — 20 seconds of shaking are enough to activate the formula. This protection of stability until use is documented by the manufacturer as a guarantee of full glutathione efficacy at the time of application. The concentrated ampoule (STEP 1) is formulated with Hippophae Rhamnoides Water (sea buckthorn water, rich in vitamin C and antioxidant carotenoids), with TXA and glutathione in positions 2 and 4 of the INCI — significant concentrations. Niacinamide (position 5) and ascorbic acid complete the anti-spot action. Thioctic acid (alpha-lipoic acid), CoQ10, cyanocobalamin (vitamin B12), and tocopherol form a complementary antioxidant network.\u003c\/p\u003e\n\u003cp\u003eThe formula is certified vegan, cruelty-free, and gluten-free. Tested on sensitive skin according to the manufacturer. No quantified efficacy data has been published for this finished product.\u003c\/p\u003e\n\u003cp\u003eActivate the formula by pressing the cap to release the powder into the ampoule, shake vigorously for 20 seconds until completely dissolved. Remove the cap and attach the applicator. Apply morning and evening to clean, toned skin, avoiding the eye area. The presence of free vitamin C (ascorbic acid) requires SPF 30 minimum sun protection in the morning.\u003c\/p\u003e\n\u003cp\u003eImportant warning: \u003cstrong\u003ehigh-purity glutathione naturally has a characteristic sulfurous odor\u003c\/strong\u003e, similar to garlic or sulfur. This odor is intrinsic to the pure glutathione molecule — it does not indicate product alteration. The manufacturer explicitly states this on the packaging and website. It dissipates after application.\u003c\/p\u003e","brand":"Numbuzin","offers":[{"title":"Default Title","offer_id":53909777547601,"sku":"PD-0505","price":25.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1032\/7094\/1009\/files\/numbuzin-no5-glutathione-txa-dark-spot-ampoule-pd-0505-square.jpg?v=1780168109"},{"product_id":"numbuzin-no9-nad-plus-bio-lifting-sil-essence-50ml-pd-0486","title":"Numbuzin — No.9+ NAD+ BIO Lifting-sil Essence 50ml","description":"\u003cp\u003eLoss of skin firmness results from multiple biological mechanisms: progressive slowing of cell renewal, decreased density of the dermal collagen and elastin network, and increased lipid peroxidation due to free radicals. The most comprehensive formulation approaches aim to act simultaneously on several of these mechanisms. The active ingredient density here is pushed to its maximum: over 100 ingredients, including more than 50 distinct peptides.\u003c\/p\u003e\n\u003cp\u003eNumbuzin's No.9+ NAD+ BIO Lifting-sil Essence is based on NAD+ (Nicotinamide Adenine Dinucleotide), a central coenzyme in cellular metabolism whose levels decline with age. In topical cosmetics, the manufacturer combines it with ATP (Adenosine Triphosphate) in a NAD+ BIO complex (NAD+, ATP, Resveratrol), described as supporting skin cell energy. This complex is supplemented by a network of 50+ peptides targeting different aspects of dermal structure: signaling peptides (Tripeptide-1, Palmitoyl Pentapeptide-4), muscle contraction peptides (Acetyl Hexapeptide-8, Dipeptide Diaminobutyroyl Benzylamide Diacetate), repair peptides (Copper Tripeptide-1, Biotinoyl Tripeptide-1), and extracellular matrix peptides (Palmitoyl Dipeptide-5, Palmitoyl Tetrapeptide-7).\u003c\/p\u003e\n\u003cp\u003eThe formula's antioxidant power is provided by the combination of Astaxanthin (Haematococcus Pluvialis Oil), Resveratrol, Glutathione, Thioctic Acid (alpha-lipoic acid), and CoQ10 (Ubiquinone). Adenosine complements the firming action. Five Saccharomyces ferments (Copper, Iron, Magnesium, Silicon, Zinc) provide additional biological support. The manufacturer's clinical study, conducted over 4 weeks, reports a visible improvement in the appearance of 11 types of wrinkles (forehead wrinkles, frown lines, crow's feet, dark circles, bunny lines, lip wrinkles, smile lines, marionette lines, mental crease, chin wrinkles, and neck wrinkles). Manufacturer data — protocol and sample sizes not disclosed.\u003c\/p\u003e\n\u003cp\u003eApply an appropriate amount to the entire face morning and evening, after cleansing and toning, before moisturizer. For enhanced targeted action on areas with pronounced wrinkles (nasolabial folds, forehead wrinkles), reapply a second layer to these areas and massage gently until fully absorbed. The velvety texture (\"Lifting-sil\") penetrates without residue or stickiness.\u003c\/p\u003e\n\u003cp\u003eFragrance-free and alcohol-free formula. The presence of Chlorhexidine Digluconate (antiseptic preservative, EU Annex V) is unusual in a face essence – caution is advised for individuals with a history of reactions to chlorinated antiseptics. Certified vegan. Not recommended during pregnancy as a precaution (highly complex formula, specific safety data for pregnancy not available).\u003c\/p\u003e","brand":"Numbuzin","offers":[{"title":"Default Title","offer_id":53909777580369,"sku":"PD-0486","price":33.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1032\/7094\/1009\/files\/numbuzin-no9-nad-plus-bio-lifting-sil-essence-50ml-pd-0486-square.jpg?v=1780168113"}],"url":"https:\/\/paradermia.com\/en\/collections\/marque-numbuzin.oembed","provider":"Paradermia","version":"1.0","type":"link"}