{"product_id":"numbuzin-no5-glutathione-txa-dark-spot-ampoule-pd-0505","title":"Numbuzin — No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate","description":"\u003cp\u003ePigmentation spots and uneven skin tone result from excessive melanin production or distribution, often exacerbated by UV, blemishes, or microtraumas. The most robustly documented anti-spot active ingredients act on several steps of the melanogenic process: TXA blocks melanocyte-keratinocyte communication; glutathione reduces tyrosinase activity and directs melanogenesis towards the lighter pheomelanin pathway; niacinamide inhibits melanosome transfer. This serum combines all three.\u003c\/p\u003e\n\u003cp\u003eNumbuzin's No.5 Glutathione TXA Advanced Dark Spot Ampoule uses a bi-dose PRESS \u0026amp; MIX galenic format. High-purity glutathione, unstable in aqueous solution, is kept in powder form (STEP 2) until activation. By pressing the cap, the powder is released into the concentrated ampoule (STEP 1) — 20 seconds of shaking are enough to activate the formula. This protection of stability until use is documented by the manufacturer as a guarantee of full glutathione efficacy at the time of application. The concentrated ampoule (STEP 1) is formulated with Hippophae Rhamnoides Water (sea buckthorn water, rich in vitamin C and antioxidant carotenoids), with TXA and glutathione in positions 2 and 4 of the INCI — significant concentrations. Niacinamide (position 5) and ascorbic acid complete the anti-spot action. Thioctic acid (alpha-lipoic acid), CoQ10, cyanocobalamin (vitamin B12), and tocopherol form a complementary antioxidant network.\u003c\/p\u003e\n\u003cp\u003eThe formula is certified vegan, cruelty-free, and gluten-free. Tested on sensitive skin according to the manufacturer. No quantified efficacy data has been published for this finished product.\u003c\/p\u003e\n\u003cp\u003eActivate the formula by pressing the cap to release the powder into the ampoule, shake vigorously for 20 seconds until completely dissolved. Remove the cap and attach the applicator. Apply morning and evening to clean, toned skin, avoiding the eye area. The presence of free vitamin C (ascorbic acid) requires SPF 30 minimum sun protection in the morning.\u003c\/p\u003e\n\u003cp\u003eImportant warning: \u003cstrong\u003ehigh-purity glutathione naturally has a characteristic sulfurous odor\u003c\/strong\u003e, similar to garlic or sulfur. This odor is intrinsic to the pure glutathione molecule — it does not indicate product alteration. The manufacturer explicitly states this on the packaging and website. It dissipates after application.\u003c\/p\u003e","brand":"Numbuzin","offers":[{"title":"Default Title","offer_id":53909777547601,"sku":"PD-0505","price":25.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1032\/7094\/1009\/files\/numbuzin-no5-glutathione-txa-dark-spot-ampoule-pd-0505-square.jpg?v=1780168109","url":"https:\/\/paradermia.com\/en\/products\/numbuzin-no5-glutathione-txa-dark-spot-ampoule-pd-0505","provider":"Paradermia","version":"1.0","type":"link"}