Argalys — Vegan Vitamin B12 1000 µg + Iodine & Selenium

This product is Argalys' most strategic for vegan profiles: B12 is the only documented deficiency that absolutely requires supplementation in a strict vegan diet, without exception. Its high-dose weekly format is biologically well-founded. Regarding the absorption mechanism: at doses ≥ 1000 µg, the passive diffusion pathway (independent of intrinsic factor) ensures ~1% absorption, or ~10 µg/dose. Adding active absorption (~2 µg), each capsule provides ~12 µg of absorbed B12. At 2 capsules/week: ~24 µg/week = ~3.4 µg/day, which is above adult needs. This weekly format is validated by the EFSA and has the advantage of adherence (fewer forgotten doses). High-dose cyanocobalamin is the scientific standard for vegan supplementation according to major nutrition societies (EFSA, ANSES). The discussion regarding methylcobalamin is relevant for profiles with MTHFR polymorphism (methylation cycle disorder), atrophic gastritis (impaired conversion), or advanced age with hypochlorhydria. These profiles benefit more from readily available methylcobalamin. Iodine (150 µg/capsule = 100% NRV) is a true differentiator of this product: insufficient iodine intake is common in vegan diets (no fish, few iodized dairy products). At 2 capsules/week, the intake is ~43 µg/day — about 29% of the daily NRV of 150 µg. This is not complete coverage, but a useful basic support. Vegans with documented iodine deficiency should supplement with other sources (calibrated algae, iodized salt). Selenium in the form of sodium selenite (inorganic) at 100 µg/capsule is well-tolerated at the weekly doses of this product (~29 µg/day at 2/week). Selenomethionine (organic) would have slightly higher bioavailability, but the inorganic form is well-absorbed and documented. The ANSES UL is 300 µg/day — a wide safety margin.